The human brain is the most complex and mysterious organ we have as humans. The three-pound blob of white and gray matter rests in the center of all human activity, you need it to fly an airplane, to eat your meal, to breathe, to run a mile, and to enjoy life itself. The brain controls the body’s basic functions such as breathing, eating, pumping blood, blinking, and anything else you do involuntarily. The brain allows you to interpret and respond to everything you experience throughout your everyday life. Emotions, shapes, thinking and talking are all regulated through the brain. The brain is made up of different sections that all work together as a single unit. Specific parts of the brain are responsible for directing and executing certain commands. Drugs can interfere with critical brain areas that are necessary for life inducing functions and can drive the drug abuse that makes addiction possible. Brain areas affected by drug abuse include the brainstem, the cerebral cortex, and the limbic system. Each part is a crucial part to everyday life and it being altered could have deadly consequences. The brainstem controls basic functions critical to life such as regulating blood pressure, sleep, expansion and contraction of the lungs, and communicates with the spinal cord. The cerebral cortex, which is split into specific groups that control specific functions. Different areas process information from our external senses such as feel, allowing us to see, hear sounds, and taste different objects. The frontal cortex, is the thinking center of the brain, powering our ability to think abstractly, plan creatively, problem solve, and make quick decisions. The limbic system, which contains the brain’s pleasure and happy center, is a very important part of the brain due to its part in giving us a sense of reward with every little thing we do. It connects a number of brain regions that control and regulate our ability to feel pleasure. The sense of pleasure motivates us to continuously reiterate behaviors that are very important to human survival. The limbic system is triggered by healthy, active errands such as eating and socializing, however, it is also activated by drug. Also, the limbic system is accountable for our understanding of people’s emotions, both upbeat and down emotions, which explains the way drugs alter our moods.The brain is a huge hub for communicating that consist of billions of neurons or nerve cells. Complex grids of neurons pass messages back and forth with the different part in the brain such as the spinal cord and nerves throughout the body. This web of neurons coordinate and regulate everything we feel, think, and do. Every single nerve cell in the brain receives and sends messages in the aspect of electrical and/or chemical signals. Once a cell receives and processes a message, it sends it on to other neurons. Neurotransmitters are the brain’s chemical messengers that are typically carried between neuron. The neurotransmitter binds to a certain spot on the receiving neuron, this is called the receptor.All drugs are just specific chemicals that rewrite the way the brain’s communication system and disrupts the way neurons normally perform, specifically impacting the process information. Certain drugs like meth and weed are very dangerous because they trigger neurons and their chemical structure mimics that of a natural neurotransmitter, confusing the brain. This causes the structures to be “fooled”, and receptors allow the drugs to attach on and activate the neurons. Although the drugs mirror the brain’s specific chemicals, they don’t release neurons in the same way compared to a natural neurotransmitter, and this leads to unusual messages being transmitted through this complex web. Other drugs like heroin or cocaine can make the neurons release weirdly large amounts of natural neurotransmitters or stop the normal repurposing of these brain chemicals. This break in the link produces a intense message that ultimately stops communication channels. Most drugs that are used in an abusive way and directly or indirectly set their sites on the brain’s reward system by flooding it with dopamine, the brains ‘happy’ chemical. Dopamine is a neurotransmitter in parts of the brain that filter movement, emotion, motivation, and feelings of pleasure. When initiated at normal levels, the system rewards our natural behaviors. Overstimulating the whole system with drugs produces euphoric effects which can be deadly in this situation. This will strongly reinforce the behavior of consistent drug use, teaching the user to repeat his dangerous habits.For the brain, the distinction between ordinary rewards and sedate rewards can be depicted as the contrast between somebody whispering into your ear and somebody yelling into a mouthpiece. Just as we turn down the volume on the radio that is too loud for our liking, the brain alters to the overpowering surges in dopamine by creating less dopamine or by decreasing the number of receptors that can get signals. As a result, dopamine’s effect on the remunerate circuit of the brain of somebody who manhandle drugs can ended up unusually low, and that person’s capacity to involvement any delight is reduced. This is why an individual who abuse drugs in the long run feels level, dead, and discouraged, and is incapable to appreciate things that were already pleasurable. Presently, the individual needs to keep taking drugs to attempt and bring his or her dopamine work back up to normal which as it makes the issue more regrettable, like a horrendous cycle. We know that the same sort of components included in the improvement of resistance can in the long run lead to significant changes in neurons and brain circuits, with the potential to seriously compromise the long-term wellbeing of the brain. For case, glutamate is another neurotransmitter that impacts the remunerate circuit and the capacity to memorize. When the ideal concentration of glutamate is changed by medication mishandle, the brain endeavors to compensate for this change, which can cause disability in cognitive work. Additionally, long-term sedate abuse can trigger adjustments in propensity or non-conscious memory frameworks. Conditioning is one illustration of this sort of learning, in which signals in a person’s every day schedule or environment gotten to be related with the medicate encounter and can trigger wild desires at whatever point the individual is uncovered to these signals, indeed in case the medicate itself is not accessible. This learned “reflex” is amazingly strong and can influence a individual who once utilized drugs indeed after numerous a long time.Incessant presentation to drugs of abuse disturbs the way basic brain structures connected to control and repress behaviors related to medicate utilize. Fair as proceeded abuse may lead to resistance or the need for higher medication doses to deliver an impact, it may too lead to enslavement, which can drive a client to look for out and take drugs compulsively. Medicate enslavement dissolves a person’s self-control and capacity to make sound choices, while creating strongly motivations to take drugs.Cannabis is the most frequently utilized illegal drug in the U.S.A., and its utilization is particularly common among teenagers and youthful grown-ups. The psychoactive chemical in cannabis, delta-9-tetrahydrocannabinol (TCH), ties with cannabinoid receptors in the brain, creating a progressing and unwinding effect. Regions of the brain with tall concentrations of cannabinoid receptors are intensely affected. One such portion of the brain, the hippocampus, oversees short-term memory, meaning that pot effects can hinder memory of other forms of recollection. Extra districts of the brain that are affected incorporate the cerebellum and basal ganglia, which offer assistance to control coordination and automatic muscle developments individually. When somebody mishandle pot, impeded engine aptitudes, temperament modifications, misshaped time and tactile discernment, diminished memory, and inconvenience considering clearly and tackling issues are all common short-term side impacts. Cannabis moreover meddles with levels of dopamine in the brain, causing the euphoric “high” that clients recall.